dna polymerase ii — TargetMol Chemicals

Cat No.	Product Name	Targets
T8972	FIT-039	Others , DNA/RNA Synthesis , CDK , HSV
	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...	Others , DNA/RNA Synthesis , CDK , HSV
T77520	AOH1996	Apoptosis , DNA/RNA Synthesis
	AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ...	Apoptosis , DNA/RNA Synthesis
T29453	5-Formylcytosine
	5-formylcytosine (5FC) is a rare base found in mammalian DNA. It participates in active DNA demethylation, changes DNA double helix structure, and reduces the transcription rate and substrate specificity of RNA polymeras...
T69931	MFH290
	MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-term...
T69908	Pidnarulex HCl
	Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhi...
T36745	CDPCP
	cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting pr...
TMIH-0025	13C-d3-AOH1996
	13C-d3-AOH1996 is the 13C and deuterated compound of AOH1996. 13C-AOH1996 has a CAS number of 2089314-64-5. AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targ...
TMIH-0091	AOH-d3
	AOH-d3 is a deuterated compound of AOH. AOH has a CAS number of 2089314-64-5. AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replic...
T75303	Suramin
	Suramin is a reversible, competitive inhibitor of protein-tyrosine phosphatases (PTPases) [1], demonstrating potent inhibition against sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) [2]. It a...

Compounds

FIT-039

T8972

Synonym:

Target: Others, DNA/RNA Synthesis, CDK, HSV

AOH1996

T77520

Synonym:

Target: Apoptosis, DNA/RNA Synthesis

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00613	DNA polymerase II Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
TMPH-00360	DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant	Cenarchaeum symbiosum	E. coli
	Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicativ...
TMPH-02380	RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)	Kluyveromyces marxianus	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precurs...
TMPH-00811	Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc)	HDV	P. pastoris (Yeast)
	Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II th...
TMPH-00533	T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)	Escherichia phage T7	E. coli
	Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short tr...
TMPY-02543	PCNA Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its ...
TMPH-00106	TBP1 Protein, Arabidopsis thaliana, Recombinant (His & SUMO)	Arabidopsis thaliana	E. coli
	General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a ro...
TMPH-02791	C-Myc Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promotin...
TMPH-01720	C-Myc Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promotin...
TMPH-01721	C-Myc Protein, Human, Recombinant (Avi & His & MBP), Biotinylated	Human	E. coli
	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promotin...
TMPY-02949	AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)	Human	E. coli
	TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of imp...